Tube of 520 MMP FRET Substrate XIII peptide
Peptides

520 MMP FRET Substrate 13 - 0.1 mg

€212.00
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  • Cat.Number : AS-60580-01
  • Availability :
    In stock

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Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
This peptide is a sensitive substrate for assaying MMP-3 and 12 activities, Abs/Em = 494/521 nm.

Specifications

Chemistry
Sequence one letter code
  • 5-FAM-RPKPVE-Nva-WRK(QXL® 520)-NH2
Sequence three letter code
  • 5-FAM-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(QXL® 520)-NH2
Molecular Mass/ Weight
  • 2144.4
Properties
Absorbance (nm)
  • 494
Emission (nm)
  • 521
Modification
Conjugation type
  • Double dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Application
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use
Codes
Code Nacres
  • NA.26

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Citations

Cyclooxygenase inhibition limits blood-brain barrier disruption following intracerebral injection of tumor necrosis factor-α in the rat.

J Pharmacol Exp Ther . 2007 Aug 17 ; 323(2) 488 | DOI : 10.1124/jpet.107.127035

  • E. Candelario-Jalil
  • et al