Example of a tube containing an Oligonucleotides with 8-Oxo-dA modification
Oligos

8-Oxo-dA - 1 modification

€92.40
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  • Cat.Number : MD-NB120-IN004
  • Availability :
    In production

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Specific modified DNA bases are usually used to study DNA damages and repair solution.
The 7-deaza purine monomers lack groups critical for hydrogen bonding.
The 8-oxo purine monomers allow investigation of the Oligo structure and activity. 8-oxo mutation occurs naturally when DNA is subjected to oxidative conditions or ionizing radiation.
5,6-Dihydro pyrimidines are naturally occurring compounds that are structural components of alanine transfer RNA.

Methylating agents are common carcinogens which function by methylation of exocyclic Amine sites in DNA. The resultant mutagenic effects can be mimicked using oligonucleotides containing methylated nucleosides like O6-Me-dG.

Specifications

Chemistry
Molecular Mass/ Weight
  • 329,21
Modification
Modification Position
  • 5'
  • IN
Storage & stability
Resuspension condition
  • - Spin the tube briefly to collect the pellet in the bottom of the tube - Add an appropriate volume of recommended buffer (refer to technical data sheet) - Allow the tube to stand a few minutes - Vortex the tube for 15 seconds
Storage Conditions
  • Dried Oligonucleotides are stable for 18 months at ambiant temperature. Oligonucleotides in solutions are stable for 24 months at -20°C. (Tolerance -20°C± 5°C. ) For more information please refer to the Reconstitution-Storage-Stability page
Activity
Usage
  • Research use
Codes
Code Nacres
  • NA.51

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