Tube of ANP(1-28) peptide, human peptide, porcine
Peptides

Atrial Natriuretic Peptide (1-28), human, porcine

€154.00
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  • Cat.Number : AS-20647
  • Availability :
    In stock

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A-type (Atrial) natriuretic peptide (ANP), also called Cardiodilatine (CDD), is a peptide hormone composed of 28 amino acids. It is processed from a 151aa prepro-ANP by signal peptide removal, followed by specific protease cleavage by corin of the pro-ANP. The 28a C-terminal peptide hormone contains a 17aa ring formed by a disulfide bridge between Cys7 and Cys23. and a tail. It is produced in cardiac myocytes, where it exerts vasodilating effects, hence playing an important role in the regulation of blood pressure and natriuresis/diuresis. Residues Phe8, Arg14 and the C-terminal sequence of ANP are known to bind to human NPR-A (Natriuretic peptide receptor type A). ANP is closely related to BNP (brain natriuretic peptide) and CNP (C-type natriuretic peptide), which share a similar ring structure.

Specifications

Chemistry
Sequence one letter code
  • SLRRSSCFGGRMDRIGAQSGLGCNSFRY (Disulfide bridge: 7-23)
Sequence three letter code
  • H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH (Disulfide bridge: 7-23)
CAS registry number
  • 89213-87-6
Molecular Formula
  • C127H203N45O39S3
Molecular Mass/ Weight
  • 3080.6
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Human, Porcine
Codes
Code Nacres
  • NA.26

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Citations

Participation of glucose transporters on atrial natriuretic peptide-induced glucose uptake by adult and neonatal cardiomyocytes under oxygenation and hypoxia.

Eur. J. Pharma . 2007 Apr 30 ; 568(1-3) 83 | DOI : 10.1016/j.ejphar.2007.04.040

  • V. Sosa
  • et al