Example of a tube of an Oligonucleotide with Cholesteryl (dR) modification
Oligos

Cholesteryl (dR) - 1 modification

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  • Cat.Number : MD-CN040-DR004
  • Availability :
    In production

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Lipophilic groups, such as cholesteryl, may enhance the permeation of cell membranes for optimal activity. This is particularly intersting for antisense oligonucleotides which must cross the cell membrane for optimal activity.
dR-Cholesteryl (deoxyribose-Cholesteryl) modification allows the synthesis of oligonucleotides containing successive molecules of Cholesteryl anywhere in the sequence or on either terminus. Each label is linked to the deoxyribose via a 6 carbon atoms spacer. Each dR-Cholesteryl can also be separated by a spacer.

Specifications

Chemistry
Spacers Sequence
  • 6 carbon atoms spacer
Molecular Mass/ Weight
  • 706,44
Modification
Modification Position
  • 3'
  • 5'
  • IN
Storage & stability
Resuspension condition
  • - Spin the tube briefly to collect the pellet in the bottom of the tube - Add an appropriate volume of recommended buffer (refer to technical data sheet) - Allow the tube to stand a few minutes - Vortex the tube for 15 seconds
Storage Conditions
  • Dried Oligonucleotides are stable for 18 months at ambiant temperature. Oligonucleotides in solutions are stable for 24 months at -20°C. (Tolerance -20°C± 5°C. ) For more information please refer to the Reconstitution-Storage-Stability page
Activity
Usage
  • Research use
Codes
Code Nacres
  • NA.51

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