Tube of Myr PKC? Pseudosubstrate peptide
Peptides

Myristolated PKCz, Pseudosubstrate (ZIP) - 1 mg

€154.00
Check your price
  • Cat.Number : AS-63361
  • Availability :
    In stock

Alternative choices

Quantity

Add to wishlist

This is a myristoylated PKC? pseudosubstrate-derived ?-inhibitory peptide (ZIP) found to inhibit an atypical type of Protein Kinase C ? (zeta). It has been shown to also interact with PKC family isoforms and disrupt conventional PKC targeting and translocation leading to physiological memory impairment. The sequence corresponds to the pseudosubstrate region of the N-terminal regulatory domain that maintains the enzyme in an inactive form in the absence of activator. The pseudosubstrate peptide has also been shown to be a competitive inhibitor of PKC? in neurons. This peptide was also used to demonstrate that PKC ? is involved in the regulation of integrin-dependent adhesion and chemotaxis of intact human neutrophils.

Specifications

Chemistry
Sequence one letter code
  • Myr-SIYRRGARRWRKL
Sequence three letter code
  • Myr-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-OH
Molecular Formula
  • C90H154N30O17
Molecular Mass/ Weight
  • 1928.5
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Application
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Human, mouse, drosophila, zebrafish, rat
Codes
Code Nacres
  • NA.26

Downloads

You may also be interested in the following product(s)

Tube of Autocamtide-2 peptide

Autocamtide-2 [KKALRRQETVDAL]

Cat.Number : AS-60249-1
€109.00 Excl. Tax
Tube of CREBtide peptide, 5-FAM

CREBtide [KRREILSRRPSYR], 5-FAM labeled

Cat.Number : AS-60436-1
€300.00 Excl. Tax
Tube of Kinase Substrate Library groupI - 1 Set peptide

Kinase Substrates Library, Group I, biotinylated, 180 distinct peptide mixtures - 1 Set

Cat.Number : AS-62017-1
€6,740.00 Excl. Tax

Citations

Protein kinase C (PKC)ζ pseudosubstrate inhibitor peptide promiscuously binds PKC family isoforms and disrupts conventional PKC targeting and translocation.

Mol Pharmcol . 2015 Jul 21 ; 88(4) 728 | DOI : 10.1124/mol.115.099457.

  • AS. Bogard
  • et al

Zeta inhibitory peptide (ZIP) erases long-term memories in a cockroach.

Neurobiol Learning Memory . 2014 Nov 27 ; 118 89 | DOI : 10.1016/j.nlm.2014.11.011

  • Z. Deng
  • et al

Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism.

J Neurosci . 2015 Apr 22 ; 35(16) 6307 | DOI : 10.1523/JNEUROSCI.3481-14.2015.

  • JV. Kim
  • et al

PKCι interacts with Rab14 and modulates epithelial barrier function through regulation of claudin-2 levels. Mol Biol

Mol Biol Cell. . 2015 Feb 18 ; 26(8) 1523 | DOI : 10.1091/mbc.E14-12-1613

  • R. Lu
  • et al

Protease activated receptor 2 (PAR2) activation is sufficient to induce the transition to a chronic pain state

Pain . 2015 May 01 ; 156(5) 859 | DOI : 10.1097/j.pain.0000000000000125.

  • DV. Tillu
  • et al

Making synapses strong: metaplasticity prolongs associativity of long-term memory by switching synaptic tag mechanisms.

Cereb Cortex . 2012 Oct 09 ; 24(2) 353 | DOI : 10.1093/cercor/bhs315.

  • Q. Li
  • et al

Inhibition of Protein kinase Mzeta (PKMζ) in the mesolimbic system alters cocaine sensitization in rats.

J Drug Alcohol Res . 2013 Jul 01 ; 2 235669 | DOI : 10.4303/jdar/235669.

  • ME. Vélez-Hernández
  • et al

Matching biochemical and functional efficacies confirm ZIP as a potent competitive inhibitor of PKMζ in neurons.

Neuropharmacol . 2012 Jul 27 ; 64 37 | DOI : 10.1016/j.neuropharm.2012.07.018

  • Y. Yao
  • et al

Inhibiting PKMζ reveals dorsal lateral and dorsal medial striatum store the different memories needed to support adaptive behavior.

Learn. Mem . 2012 Jan 01 ; 19 307 | DOI : 10.1101/lm.025148.111

  • WM. Pauli
  • et al

Metabotropic actions of the volatile anaesthetic sevoflurane increase protein kinase Mζ synthesis and induce immediate preconditioning protection of rat hippocampal slices.

J Physiol . 2012 Jun 06 ; 590(16) 4093 | DOI : 10.1113/jphysiol.2012.233965

  • J. Wang
  • et al

Cellular pharmacology of protein kinase Mζ (PKMζ) contrasts with its in vitro profile: implications for PKMζ as a mediator of memory

J Biol Chem . 2012 Feb 29 ; 287(16) 12879 | DOI : 10.1074/jbc.M112.357244

  • AX. Wu-Zhang
  • et al

PKMζ maintains 1‐day‐and 6‐day‐old long‐term object location but not object identity memory in dorsal hippocampus.

Hippocampus . 2010 Jun 01 ; 20(6) 691 | DOI : 10.1002/hipo.20708

  • O. Hardt
  • et al

PKMζ maintains memories by regulating GluR2-dependent AMPA receptor trafficking.

Nat Neurosci . 2010 Apr 11 ; 13(5) 630 | DOI : 10.1038/nn.2531.

  • P. Migues
  • et al

PKCι interacts with Rab14 and modulates epithelial barrier function through regulation of claudin-2 levels. Mol Biol Cell, mbc-E14.

Mol Biol Cell. . 2015 Feb 18 ; 26(8) 1523 | DOI : 10.1091/mbc.E14-12-1613

  • R. Lu
  • et al