Tube of PAR-4 Agonist amide peptide
Peptides

Protease-Activated Receptor-4, PAR-4 Agonist, amide

€87.00
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  • Cat.Number : AS-60218-1
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This PAR-4 agonist peptide stimulates thromboxane production by human platelets with the maximal response to this agonist being approximately half of that observed after maximal thrombin stimulation.

Specifications

Chemistry
Sequence one letter code
  • AYPGKF-NH2
Sequence three letter code
  • H-Ala-Tyr-Pro-Gly-Lys-Phe-NH2
CAS registry number
  • 352017-71-1
Molecular Formula
  • C34H48N8O7
Molecular Mass/ Weight
  • 680.8
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human
Codes
Code Nacres
  • NA.26

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Citations

CIB1 deficiency results in impaired thrombosis: the potential role of CIB1 in outside-in signaling through integrin alpha IIb beta 3.

J Thrombosis Haemostasis . 2009 Aug 19 ; 7(11) 1906 | DOI : 10.1111/j.1538-7836.2009.03581.x

  • MU. Naik
  • et al

Platelets from mice lacking the aryl hydrocarbon receptor exhibit defective collagen-dependent signaling

J Thrombosis Haemostasis . 2014 Jan 01 ; 12(3) 383 | DOI : 10.1111/jth.12490

  • S. Lindsey
  • et al

JAM-A protects from thrombosis by suppressing integrin αIIbβ3-dependent outside-in signaling in platelets

Blood . 2012 Jan 23 ; 119(14) 3352 | DOI : 10.1182/blood-2011-12-397398

  • MU. Naik
  • et al

Ticagrelor effectively and reversibly blocks murine platelet P2Y12-mediated thrombosis and demonstrates a requirement for sustained P2Y12 inhibition to prevent subsequent neointima

Am Heart Assoc . 2010 Nov 11 ; 30(12) 2385 | DOI : 10.1161/ATVBAHA.110.210732

  • SB. Patil
  • et al

Bile salt–dependent lipase interacts with platelet CXCR4 and modulates thrombus formation in mice and humans

J Clinical Invest . 2007 Dec 01 ; 117(12) 3708 | DOI : 10.1172/JCI32655

  • L. Panicot-Dubois
  • et al

P2X1 stimulation promotes thrombin receptor-mediated platelet aggregation

J Thrombosis Haemostasis . 2006 Apr 01 ; 4(4) 882 | DOI : 10.1111/j.1538-7836.2006.01849.x

  • JA. Erhard
  • et al

Characterization of the in vivo antiplatelet activity of the antihypertensive agent losartan

J Cardiovasc Pharmacol Ther . 2011 Nov 28 ; 17(3) 308 | DOI : 10.1177/1074248411425491

  • JP. Murad
  • et al

Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms 1

J Immunol . 2005 Aug 15 ; 175(4) 2598 | DOI : 10.4049/jimmunol.175.4.2598

  • X. Su
  • et al

Protease activated receptor-1, but not -2, -3 and -4, is the player in the pathogenesis of atrial fibrosis; The experiment by neonatal rat atrial fibroblasts.

Int J Cardiol Heart Vessel.  . 2013 Nov 13 ; 2 21 | DOI : 10.1016/j.ijchv.2013.11.005

  • I. Keiichi
  • et al

Thrombin- and Factor Xa–induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells.

Circ. Res . 2003 Dec 11 ; 94(3) 340 | DOI : 10.1161/01.RES.0000111805.09592.D8

  • BH. Rauch
  • et al

Thrombin and factor Xa-induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells

Circ Res. . 2003 Dec 11 ; 94(3) 340 | DOI : 10.1161/01.RES.0000111805.09592.D8

  • BH. Rauch
  • et al

Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells

Blood . 2003 Jul 17 ; 102(9) 3224 | DOI : 10.1182/blood-2003-04-1130

  • H. Kataoka
  • et al