Tube of PUMA BH3 peptide
Peptides

PUMA BH3 - 1 mg

€240.00
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  • Cat.Number : AS-62404
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This is a PUMA (p53 upregulated modulator of apoptosis) BH3 domain peptide. PUMA together with Bcl-xL, and cytoplasmic p53 coordinates p53 functions. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome C release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.

Specifications

Chemistry
Sequence one letter code
  • EEQWAREIGAQLRRMADDLNAQYER
Sequence three letter code
  • H-Glu-Glu-Gln-Trp-Ala-Arg-Glu-Ile-Gly-Ala-Gln-Leu-Arg-Arg-Met-Ala-Asp-Asp-Leu-Asn-Ala-Gln-Tyr-Glu-Arg-OH
Molecular Formula
  • C128H202N42O43S1
Molecular Mass/ Weight
  • 3049.5
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human
Codes
Code Nacres
  • NA.26

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Citations

Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins.

PNAS . 2008 Dec 23 ; 105(51) 20327 | DOI : 10.1073/pnas.0808036105

  • J. Chipuk
  • et al