Peptides

Substance P

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  • Cat.Number : AS-24279
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Substance P (SP) is an important neuropeptide belonging to the tachykinin family. It acts as a neurotransmitter and neuromodulator. It is closely related to neurokinin A, both originating from the same precursor preprotachykinin A. It is released from the terminals of sensory nerves and is involved in inflammation and pain processes.

Specifications

Chemistry
Sequence one letter code
  • RPKPQQFFGLM-NH2
Sequence three letter code
  • H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
CAS registry number
  • 33507-63-0
Molecular Formula
  • C63H98N18O13S
Molecular Mass/ Weight
  • 1347.7
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • guinea pig
Codes
Code Nacres
  • NA.26

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Citations

GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin

Proc Natl Acad Sci U S A. . 2013 May 20 ; 110(23) 9529 | DOI : 10.1073/pnas.1219004110

  • RC. Meyer
  • et al

Inhibition of a secreted glutamic peptidase prevents growth of the fungus Talaromyces emersonii

J Biol Chem. . 2008 Aug 07 ; 283(43) 29186 | DOI : 10.1074/jbc.M802366200

  • AJ. O'Donoghue
  • et al

A homogeneous enzyme fragment complementation-based β-arrestin translocation assay for high-throughput screening of G-protein-coupled receptors

J Biomol Screen. . 2008 Jul 25 ; 13(8) 737 | DOI : 10.1177/1087057108321531

  • X. Zhao
  • et al