Tube of Thrombospondin inhibitor peptide
Peptides

Thrombospondin (TSP-1) Inhibitor, LSKL - 1 mg

€87.00
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  • Cat.Number : AS-60877
  • Availability :
    In stock

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This peptide, derived from the latency-associated peptide, inhibits thrombospondin (TSP-1) activation of TGF-ß, thus preventing the progression of hepatic damage and fibrosis.

Specifications

Chemistry
Sequence one letter code
  • LSKL-NH2
Sequence three letter code
  • H-Leu-Ser-Lys-Leu-NH2
CAS registry number
  • 283609-79-0
Molecular Formula
  • C21H42N6O5
Molecular Mass/ Weight
  • 458.6
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human
Codes
Code Nacres
  • NA.26

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Citations

Stainless steel ions stimulate increased thrombospondin-1-dependent TGF-Beta activation by vascular smooth muscle cells: implications for in-stent restenosis

Vasc Res . 2009 Dec 16 ; 47(4) 309 | DOI : 10.1159/000265565.

  • MA. Pallero
  • et al

Glucose downregulation of PKG-I protein mediates increased thrombospondin1-dependent TGF-β activity in vascular smooth muscle cells.

Am J Physiol Cell Physiol . 2010 Feb 17 ; 298(5) C1188 | DOI : 10.1152/ajpcell.00330.2009.

  • S. Wang
  • et al

LSKL, a peptide antagonist of thrombospondin-1, attenuates renal interstitial fibrosis in rats with unilateral ureteral obstruction.

Archives Pharmac Res . 2010 Feb 24 ; 33(2) 275 | DOI : 10.1007/s12272-010-0213-6.

  • X. Xie
  • et al

A thrombospondin-1 antagonist of transforming growth factor-beta activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin II.

Am J Pathol . 2007 Sep 01 ; 171(3) 777 | DOI : 10.2353/ajpath.2007.070056.

  • S. Belmadani
  • et al

Thy-1 Expression Regulates the Ability of Rat Lung Fibroblasts to Activate Transforming Growth Factor-β in Response to Fibrogenic Stimuli

Am J Pathol . 2004 Aug 01 ; 165(2) 659 | DOI : 10.1016/s0002-9440(10)63330-5

  • Y. Zhou
  • et al

Kidney transplantation: analysis of the expression and T cell-mediated activation of latent TGF-beta

J Leukoc Biol. . 2012 Nov 27 ; 93(4) 471 | DOI : 10.1189/jlb.0712324

  • J. Willet
  • et al

Amino acids induce indicators of response to injury in glomerular mesangial cells

Am J Physiol Renal Physiol. . 2003 Mar 18 ; 285(1) F79 | DOI : 10.1152/ajprenal.00419.2002

  • R.L. Meek
  • et al