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CATALOG PEPTIDES
Parathyroid hormone related Peptides
Calcium Homeostasis
Calcium homeostasis is finely regulated by Parathyroid Hormone (PTH), Calcitonin and Vitamin D.
A decrease in blood calcium concentration triggers the release of PTH from the parathyroid glands. This 84-amino acid hormone plays important roles in calcium homeostasis of bone, kidney, breast, and placenta. PTH signals via the PTH/PTHrP and PTH2 receptors. PTH (1–34) administration suppresses cardiovascular calcification and down-regulates aortic osteogenic programs driven by diabetes and dyslipidemia.
An increase of calcium concentration, stimulates the release of Calcitonin, a 32-amino acid peptide from the thyroid parafollicular cells (C-cells).
References
- Khan, MM. and Desborough JP. , Pharmacology 19, 1 (2005)
- Stevenson, RW andParsons JA , J. Endo. 97, 21 (1983)
- Newman, W. et al. J. Biol. Chem. 264, 16359 (1989)
- Brennan, DP. and Levine MA., J. Biol. Chem. 262, 14795 (1987)
- Broadus, AE. et al. N. Engl. J. Med. 319, 556 (1988)