Tube of Human MMP-1 (Catalytic Domain), Recombinant protein
Protein

MMP-1 (Catalytic Domain), human recombinant

€115.00
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  • Cat.Number : AS-55575-1
  • Availability :
    In stock
  • Shipping conditions : Ice delivery fees must be applied

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Matrix metalloproteinases (MMP’s) belong to a family of secreted or membrane-associated zinc endopeptidases capable of digesting extracellular matrix components. MMP-1 (collagenase-1) is involved in tumor development and metastasis and rheumatoid arthritis. It is proposed as a therapeutic target for these diseases. MMP-1 digests a broad range of substrates, including α-1 antitrypsin, myelin basic protein, collagen I, II, III, VII, VIII, casein, gelatin, and others

The sequence (Accession # NP_002412) corresponding to the catalytic domain (aa 106-261) of Human MMP-1 was expressed in E. coli. The recombinant human MMP-1 was purified from bacterial lysate and refolded using proprietary technique. The molecular weight of the recombinant Human MMP-1 Catalytic Domain is ~17.5 kDa.

Specifications

Chemistry
UniProt number
  • P03956 (pro-MMP-1)
Molecular Mass/ Weight
  • 17.5 kDa
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Concentration
  • lot dependent
Purification Method
  • Purified
Purity
  • >95%
Storage & stability
Form
  • In solution
Storage Buffer
  • 300 mM NaCl, 20 mM Tris-HCl, 10 mM CaCl2, 1 µM ZnCl2, pH=7.5
Storage Conditions
  • Store at -80 ºC. Avoid repeated freeze-thaw cycles
Activity
Application
Biomarker Target
Specificity
  • Catalytic domain (aa 106-261) of Human MMP-1
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Host
Source / Species
  • human
Codes
Code Nacres
  • NA.27

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